Does activation of mitophagy protect against high fat diet-induced diabetic cardiomyopathy?
High fat diet (HFD)-induced diabetic cardiomyopathy model
Modulation (impairment or activation) of mitophagy
Mitochondrial dysfunction, lipid accumulation, and diabetic cardiomyopathy severitysurrogate
Mitophagy plays a critical protective role against high fat diet-induced diabetic cardiomyopathy by preventing mitochondrial dysfunction and lipid accumulation.
Mitophagy serves as an essential quality control mechanism for mitochondria in the heart during HFD consumption. Impairment of mitophagy induces mitochondrial dysfunction and lipid accumulation, thereby exacerbating diabetic cardiomyopathy. Conversely, activation of mitophagy protects against HFD-induced diabetic cardiomyopathy.
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Mingming Tong
Toshiro Saito
Peiyong Zhai
Circulation Research
Rutgers, The State University of New Jersey
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Tong et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d81f8e8c03fbaff8bedd6f — DOI: https://doi.org/10.1161/circresaha.118.314607