Empagliflozin improved cardiac diastolic function, reducing the time constant of relaxation (Tau) from 15.1 ms to 13.5 ms, and reduced left ventricular mass in a nondiabetic rodent model of HFpEF.
Absolute Event Rate: 13.5% vs 15.1%
p-value: p=<0.05
Recent studies send an unambiguous signal that the class of agents known as sodium-glucose-linked co-transporter-2 inhibitors (SGLT2i) prevent heart failure hospitalization in patients with type 2 diabetes. However, the mechanisms remain unclear. Herein the authors utilize a rodent model of heart failure with preserved ejection fraction (HFpEF), and demonstrate that treatment with the SGLT2i empagliflozin, reduces left ventricular mass, improving both wall stress and diastolic function. These findings extend the observation that the main mechanism of action of empagliflozin involves improved hemodynamics (i.e., reduction in preload and afterload) and provide a rationale for upcoming trials in patients with HFpEF irrespective of glycemic status.
Connelly et al. (Fri,) conducted a other in Heart failure with preserved ejection fraction (HFpEF) (n=46). Empagliflozin vs. Control diet (vehicle) was evaluated on Diastolic function (time constant of relaxation, Tau) in ms (p=<0.05). Empagliflozin improved cardiac diastolic function, reducing the time constant of relaxation (Tau) from 15.1 ms to 13.5 ms, and reduced left ventricular mass in a nondiabetic rodent model of HFpEF.