Is excessive visceral adiposity associated with impaired left ventricular diastolic function in subjects without overt cardiac diseases?
Excessive visceral adiposity is associated with impaired left ventricular diastolic function in individuals without overt cardiac disease, and this relationship does not appear to be directly mediated by serum adiponectin levels.
We evaluated the association between visceral adiposity and left ventricular (LV) diastolic function in association with plasma adiponectin levels in 213 subjects without overt cardiac diseases. Abdominal visceral fat area was quantified by computed tomography. Excessive visceral fat was significantly associated with impaired diastolic parameters including E/A, E' and E/E'. Although serum adiponectin levels decreased with increased visceral adiposity, there was no independent association between serum adiponectin levels and diastolic parameters, which suggest that the role of adiponectin in this association might be indirect.
Sawada et al. (Thu,) studied this question.