Low-to-standard dose dual combination therapy (1+1 dose) improved BP control compared with standard-dose monotherapy (RR 1.42; 95% CI 1.27-1.58) without increasing adverse withdrawals.
Meta-Analysis (n=13,095)
Does dual combination therapy of blood pressure-lowering drugs as initial treatment improve BP control and reduce SBP compared to standard-dose monotherapy in adults with hypertension?
Initiating hypertension treatment with low-to-standard dose dual combination therapy provides greater BP reduction than standard-dose monotherapy without increasing adverse event withdrawals.
Effect estimate: RR 1.42 (95% CI 1.27-1.58)
OBJECTIVE: To assess the efficacy and tolerability of dual combination of blood pressure (BP)-lowering drugs as initial treatment for hypertension. METHODS: MEDLINE, Embase, CENTRAL were searched until August 2017 for randomized, double-blind trials of dual combination therapy vs. monotherapy in adults with hypertension who were either treatment naïve or untreated for at least 4 weeks. Regimens were classified with reference to usual daily 'standard-dose'; for example, <1 + <1 for a combination of two drugs both at less than one standard-dose. Random-effects models were used for meta-analysis. RESULTS: Thirty-three trials (13 095 participants) with mean baseline mean BP 155/100 mmHg were included. Compared with standard-dose monotherapy, dual combinations of <1 + <1, 1 + <1 and 1 + 1 (i.e. low-to-standard dose), showed a dose-response relationship in reducing SBP mean differences (95% confidence interval) of 2.8 (1.6-4.0), 4.6 (3.4-5.7) and 7.5 (5.4-9.5) mmHg, respectively, and in improving BP control risk ratio (RR) (95% confidence interval) 1.11 (0.92-1.34), 1.25 (1.16-1.35) and 1.42 (1.27-1.58), respectively. Withdrawals due to adverse events were uncommon with low-to-standard dose dual combinations, with no significant difference compared with standard-dose monotherapy 2.9 vs. 2.2%; RR 1.28 (0.85 to 1.92). There were fewer data for higher dose dual combinations, which did not appear to produce substantial additional efficacy and could potentially be less tolerable. CONCLUSION: Compared with standard-dose monotherapy, initiating treatment with low-to-standard dose dual combination therapy is more efficacious without increasing withdrawals due to adverse events. PROSPERO REGISTRATION: CRD42016032822.
Salam et al. (Sat,) conducted a meta-analysis in Hypertension (n=13,095). Dual combination therapy of blood pressure-lowering drugs vs. Standard-dose monotherapy was evaluated on Blood pressure control (1 + 1 standard-dose dual combination vs standard-dose monotherapy) (RR 1.42, 95% CI 1.27-1.58). Low-to-standard dose dual combination therapy (1+1 dose) improved BP control compared with standard-dose monotherapy (RR 1.42; 95% CI 1.27-1.58) without increasing adverse withdrawals.