Bioprosthetic heart valves provide effective treatment for valvular heart disease without the need for anticoagulation, but their long-term durability remains limited by age-dependent structural valve degeneration and immune-mediated calcification.
Prosthetic heart valves have been commonly used to address the increasing prevalence of valvular heart disease. The ideal prosthetic heart valve substitute should closely mimic the characteristics of a normal native heart valve. Despite the development of various interventions, an exemplary valve replacement does not exist. This review provides an overview of the novel engineering valve designs and explores emergent immunologic insights into age-dependent structural valve degeneration (SVD).
Kan Yan Chloe Li (Thu,) conducted a review in Valvular heart disease. Bioprosthetic heart valves vs. Mechanical heart valves was evaluated. Bioprosthetic heart valves provide effective treatment for valvular heart disease without the need for anticoagulation, but their long-term durability remains limited by age-dependent structural valve degeneration and immune-mediated calcification.