Does lifelong physical activity affect genotype-to-phenotype transition, LV wall thickness, or arrhythmic burden in HCM gene carriers and patients?
Lifelong physical activity does not appear to drive structural phenotypic transition in HCM gene carriers, but high activity levels may be associated with earlier diagnosis and increased arrhythmic burden.
Lifelong physical activity volumes are not associated with genotype-to-phenotype transition in HCM gene carriers. We also found no difference in LV wall thickness across physical activity tertiles. However, the most active HCM patients were younger at the time of diagnosis and had a higher arrhythmic burden. These observations warrant further exploration of the role of exercise in HCM disease development.
Aengevaeren et al. (Thu,) studied this question.