A standardized oral fat tolerance test is recommended for ASCVD risk prediction when fasting triglycerides are 1-2 mmol/L or non-fasting triglycerides are 1.3-2.3 mmol/L.
Does a standardised Oral Fat Tolerance Test improve ASCVD risk prediction in individuals with borderline triglyceride levels?
An expert panel statement proposes a standardised Oral Fat Tolerance Test to identify postprandial hypertriglyceridaemia in patients with borderline triglyceride levels to better assess residual cardiovascular risk.
Residual vascular risk exists despite the aggressive lowering of Low-Density Lipoprotein Cholesterol (LDL-C). A contributor to this residual risk may be elevated fasting, or non-fasting, levels of Triglyceride (TG)-rich lipoproteins. Therefore, there is a need to establish whethe a standardised Oral Fat Tolerance Test (OFTT) can improve atherosclerotic Cardiovascular (CV) Disease (ASCVD) risk prediction in addition to a fasting or non-fasting lipid profile. An expert panel considered the role of postprandial hypertriglyceridaemia (as represented by an OFTT) in predicting ASCVD. The panel updated its 2011 statement by considering new studies and various patient categories. The recommendations are based on expert opinion since no strict endpoint trials have been performed. Individuals with fasting TG concentration 2.5 mmol/L (220 mg/dL). Postprandial hypertriglyceridaemia is an emerging factor that may contribute to residual CV risk. This possibility requires further research. A standardised OFTT will allow comparisons between investigational studies. We acknowledge that the OFTT will be mainly used for research to further clarify the role of TG in relation to CV risk. For routine practice, there is a considerable support for the use of a single non-fasting sample.
Kolovou et al. (Tue,) conducted a review in Postprandial hypertriglyceridaemia and ASCVD risk. Oral Fat Tolerance Test (OFTT) was evaluated. A standardized oral fat tolerance test is recommended for ASCVD risk prediction when fasting triglycerides are 1-2 mmol/L or non-fasting triglycerides are 1.3-2.3 mmol/L.