Computational haemodynamics modeling of six patient-specific cerebral aneurysms characterized the near-wall flow field using wall shear stress and its divergence across the cardiac cycle.
This computational study outlines numerical methods to analyze near-wall flow fields in cerebral aneurysms, which are critical for understanding disease formation and vascular remodeling.
The region where the vascular lumen meets the surrounding endothelium cell layer, hence the interface region between haemodynamics and cell tissue, is of primary importance in the physiological functions of the cardiovascular system. The functions include mass transport to/from the blood and tissue, and signalling via mechanotransduction, which are primary functions of the cardiovascular system and abnormalities in these functions are known to affect disease formation and vascular remodelling. This region is denoted by the near-wall region in the present work, and we outline simple yet effective numerical recipes to analyse the near-wall flow field. Computational haemodynamics solutions are presented for six patient specific cerebral aneurysms, at three instances in the cardiac cycle: peak systole, end systole (taken as dicrotic notch) and end diastole. A sensitivity study, based on Newtonian and non-Newtonian rheological models, and different flow rate profiles, is effected for a selection of aneurysm cases. The near-wall flow field is described by the wall shear stress (WSS) and the divergence of wall shear stress (WSSdiv), as descriptors of tangential and normal velocity components, respectively, as well as the wall shear stress critical points. Relations between near-wall and free-stream flow fields are discussed.
Ardakani et al. (Thu,) conducted a other in Cerebral aneurysms (n=6). Computational haemodynamics modeling was evaluated on Near-wall flow field described by wall shear stress (WSS) and divergence of wall shear stress (WSSdiv). Computational haemodynamics modeling of six patient-specific cerebral aneurysms characterized the near-wall flow field using wall shear stress and its divergence across the cardiac cycle.