3D strains and strain rates derived from the homologous times approach identified left atrial functional remodeling in patients with paroxysmal atrial fibrillation and hypertension, achieving an AUC of 0.937 for discriminating controls from PAF patients.
Cross-Sectional (n=130)
No
Does 3D speckle tracking echocardiography using homologous times improve the detection of left atrial remodeling in patients with hypertension and paroxysmal atrial fibrillation compared to standard parameters?
Novel 3D speckle tracking echocardiography parameters using homologous times provide superior discrimination of left atrial functional remodeling in patients with paroxysmal atrial fibrillation compared to standard 2D and 3D parameters.
p-value: p=<0.001
The function of left atrium (LA) is closely related to LA remodeling and one of the most important mechanisms is an increased deposition of fibrous tissue that often is the basis for LA electro-mechanical changes before the onset of atrial fibrillation (AF). This study evaluated LA shape and function, by investigating standard and novel strain parameters calculated by a new approach based on homologous times derived from 3D speckle tracking echocardiography (3DSTE) in hypertensive (HT) and paroxysmal atrial fibrillation (PAF) patients with or without left ventricular hypertrophy (LVH), compared to control (C) subjects. LA function was assessed using homologous times to compare strain variables among different individuals, acquired at different physiological time periods. Standard global longitudinal (GLS) and circumferential (GCS) strains were measured at peak of atrial diastole, while longitudinal and circumferential strains (GLSh, GCSh), strain rate (GLSr, GCSr), volume (Vh) and volume rate (Vr) were measured during the atrial telediastolic phase (fifth homologous time) and atrial pre-active phase (tenth homologous time). Using ANOVA, we found an impaired LA deformation detected by standard, interpolated strains and strain rates in both HT and PAF groups compared to C. We also performed ROC analysis to identify different performances of each parameter to discriminate groups (GLSr10 + GCSr10: C vs PAF 0. 935; C vs PAFLVH 0. 924; C vs HTLVH 0. 844; C vs HT 0. 756). Our study showed anatomical and functional LA remodeling in patients with PAF and HT. 3D strains and strain rates derived from the homologous times approach provide more functional information with improved performance to identify among the explored groups, in particular PAF patients.
Esposito et al. (Tue,) conducted a cross-sectional in Arterial hypertension and paroxysmal atrial fibrillation (n=130). Hypertension and paroxysmal atrial fibrillation vs. Healthy control subjects was evaluated on Left atrial deformation (strain and strain rate) and classification performance (AUC) to discriminate groups (p=<0.001). 3D strains and strain rates derived from the homologous times approach identified left atrial functional remodeling in patients with paroxysmal atrial fibrillation and hypertension, achieving an AUC of 0.937 for discriminating controls from PAF patients.