Platelet to lymphocyte ratio (PLR) values were significantly lower in patients with a normal appendix compared to those with acute or perforated appendicitis (p<0.001).
Observational (n=558)
Does the platelet to lymphocyte ratio (PLR) help in the pre-operative diagnosis and differentiation of acute appendicitis and perforated appendicitis?
PLR and NLR can serve as valuable pre-operative biomarkers to differentiate between a normal appendix, acute appendicitis, and perforated appendicitis.
p-value: p=<0.001
Abstract Background: Recently, the possible use of laboratory parameters such as full blood count, neutrophil count, neutrophil to lymphocyte ratio (NLR), thrombocyte count (PLT), and mean thrombocyte volume (MPV) have been investigated in diagnosis of acute appendicitis and the prediction of complications. The aim of this study was to investigate the utility of the platelet to lymphocyte ratio (PLR) value as a biomedical marker in the prediction of acute appendicitis and perforated appendix. Patients and Methods: The data were retrieved from the hospital records related to age, gender, length of stay in hospital, MPV, leukocyte, neutrophil, lymphocyte, and thrombocyte counts measured in the peripheral venous blood sample on presentation, NLR and PLR values, and the pathology results. The patients were grouped according to the pathology results as follows: group 1 (normal appendix, n = 86); group 2 (acute appendicitis, n = 458); group 3 (perforated appendicitis, n = 14). Results: The study included a total of 558 patients (308 males; 250 females) with a mean age of 34.24 ± 14.27 years. The mean length of stay in hospital was 2.12 days. The leukocyte and neutrophil count values of group 1 were lower than group 2 and group 3 values (p < 0.001). The lymphocyte count values of group 1 were higher than those of the other groups (p < 0.001). The NLR and PLR values of group 1 were lower than group 2 and group 3 values (p < 0.001). The length of stay in hospital was shorter in group 1 than in group 2 and group 3 (p = 0.42). The receiver operating characteristic (ROC) curve test results showed that PLR and NLR values were sensitive and specific to differentiate normal appendix, acute appendicitis, and perforated appendicitis. Conclusion: The results of this study demonstrated that PLR value, such as NLR, could be evaluated as a new biomarker that could be valuable in the differentiation of normal appendix from acute appendicitis and in the differentiation of acute appendicitis from perforated appendicitis.
Pehlivanlι et al. (Thu,) conducted a observational in Acute appendicitis (n=558). Platelet to lymphocyte ratio (PLR) vs. Normal appendix was evaluated on Differentiation of normal appendix, acute appendicitis, and perforated appendicitis (p=<0.001). Platelet to lymphocyte ratio (PLR) values were significantly lower in patients with a normal appendix compared to those with acute or perforated appendicitis (p<0.001).
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