A correlation between the phenotype of a chemosensory unit and distinct components of the reflex response could permit differential modulation of chemoreflex responses for therapeutic exploitation.
The carotid body has emerged as a therapeutic target for cardio-respiratory-metabolic diseases. With the expansive functions of the chemoreflex, we sought mechanisms to explain differential control of individual responses. We purport a remarkable correlation between phenotype of a chemosensory unit (glomus cell-sensory afferent) with a distinct component of the reflex response. This logic could permit differential modulation of distinct chemoreflex responses, a strategy ideal for therapeutic exploitation.
Żera et al. (Wed,) conducted a review in Cardio-respiratory-metabolic diseases. A correlation between the phenotype of a chemosensory unit and distinct components of the reflex response could permit differential modulation of chemoreflex responses for therapeutic exploitation.