α-Trialkylsilyl-Substitutedα-Amino Acids

And they are stable! Rhodium-catalyzed transformations of α-trialkylsilyl-α-diazoacetates with amidic reactants afford chiral α-silyl-substituted amino acid derivatives 1 in good yields. The enantiomers can be separated and are configurationally stable. Deprotection affords free α-trialkylsilyl-α-amino acetic acids. Incorporation of the latter into peptidic structures such as 2 is possible under standard conditions for peptide coupling. PG=protecting group.