January 1, 2019Open Access

Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study

Key Result

Computed tomography-based abdominal aortic calcification was evaluated for the prediction of left ventricular diastolic dysfunction and cardiovascular risk in pre-dialysis patients.

Structured PICO

Does CT-based abdominal aortic calcification predict left ventricular diastolic dysfunction and future cardiovascular events in asymptomatic pre-dialysis CKD patients?

Population

218 asymptomatic pre-dialysis chronic kidney disease (CKD) patients (eGFR <60 mL/min/1.73 m2 or proteinuria), mean age 68, 70% male, from a single center in Japan. Key exclusions: previous admission due to HF, history of percutaneous coronary intervention, previous abdominal aortic artery repair or stenting, cardiac systolic dysfunction (EF <50%), left ventricular dilatation (LVEDV >97 mL/m2), moderate or severe valvular heart disease, and atrial fibrillation.

Intervention

Computed tomography (CT)-based assessment of abdominal aortic calcification (AAC) using the aortic calcification index (ACI)

Comparator

Low abdominal aortic calcification (ACI ≤ 20)

Outcome

Left ventricular diastolic dysfunction (LVDD) and a composite of cardiovascular death, hospitalization for stroke, acute coronary syndrome, angina pectoris requiring revascularization, and HF requiring admission at median 1236 days follow-upcomposite

CT-assessed abdominal aortic calcification is a useful non-invasive marker for predicting latent left ventricular diastolic dysfunction and future cardiovascular events in asymptomatic pre-dialysis CKD patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

There is general interest in finding clinical markers for left ventricular diastolic dysfunction (LVDD), a major cause of cardiorenal syndrome leading to heart failure in chronic kidney disease (CKD) patients. The aim was to assess the utility of computed tomography (CT)-based abdominal aortic calcification (AAC) for the prediction of LVDD and prognosis of asymptomatic pre-dialysis CKD patients.

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