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Despite the perceived stability of the C-F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists' attention.
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Yue Pan (Thu,) studied this question.
www.synapsesocial.com/papers/69de6a40bf539e2270558800 — DOI: https://doi.org/10.1021/acsmedchemlett.9b00235
Yue Pan
ACS Medicinal Chemistry Letters
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