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Abstract N ‐( p ‐Nitrophenoxy)carbonyl‐3‐morpholino‐sydnonimine (NCMS) has been prepared from 3‐morpholinosydnonimine hydrochloride. Using the Griess assay and the superoxide‐mediated reduction of ferricytochrome c, the nitric oxide (NO•) and superoxide anion (O 2 • ‐ ) ‐ releasing properties in phosphate buffer pH 7.4 of this novel peroxynitrite donor was studied and compared with the known 3‐morpholino‐sydnonimine (SIN‐1). From compound NCMS, a series of N‐substituted sydnonimine derivatives were easily prepared that contain purine or melaminophenyl groups which specify a recognition by a trypanosomal purine transporter. The ability of these new sydnonimines to inhibit the uptake of 2 3 Hadenosine on Trypanosoma equiperdum was studied.
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Laurent Soulère
Pascal Hoffmanna
Frédéric Bringaud
Journal of Heterocyclic Chemistry
Centre National de la Recherche Scientifique
Université Toulouse III - Paul Sabatier
Molécules d'Intérêt Biologique
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Soulère et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69da262d34ded318bb684643 — DOI: https://doi.org/10.1002/jhet.5570400533