There is no robust evidence to support that arterial stiffness can be considered reversible other than as a direct consequence of reduction in blood pressure in patients with CKD.
Can arterial stiffness be considered a reversible cardiovascular risk factor independent of blood pressure reduction in patients with chronic kidney disease?
Arterial stiffness in CKD is currently an indirectly modifiable risk factor via blood pressure control, rather than a direct therapeutic target.
PURPOSE OF REVIEW: There is an inverse, graded relationship between worsening chronic kidney disease (CKD) and increasing cardiovascular risk independent of traditional cardiovascular risk factors. Increasing arterial stiffness is a powerful predictor of cardiovascular outcomes in CKD. Developing novel therapeutic strategies to reverse this process is an attractive concept. This review presents the results of a literature survey of the last 18 months to establish if arterial stiffness can be considered a reversible cardiovascular risk factor in patients with CKD. RECENT FINDINGS: Multiple potential therapeutic approaches to reduce arterial stiffness have been proposed and tested. However, arterial stiffness and blood pressure (BP) have a very close bidirectional relationship. Any change in BP will have an effect on arterial stiffness and vice versa. At present, there is no robust evidence to support the notion that arterial stiffness can be considered reversible other than as a direct consequence of reduction in BP. SUMMARY: For now, arterial stiffness should be considered an indirectly modifiable cardiovascular risk factor through optimal control of BP. Measures of arterial stiffness should be regarded as research and risk stratification tools rather than a therapeutic target in itself.
Pickup et al. (Mon,) conducted a review in Chronic kidney disease (CKD). Therapeutic approaches to reduce arterial stiffness was evaluated on Reversibility of arterial stiffness. There is no robust evidence to support that arterial stiffness can be considered reversible other than as a direct consequence of reduction in blood pressure in patients with CKD.