Higher android fat deposition in overweight young males was associated with significantly reduced endothelial function (RHI 1.64 vs 2.26) and impaired metabolic profile compared to lower android fat.
Cross-Sectional (n=46)
Yes
Does a higher android fat distribution worsen hemodynamic, metabolic, or vascular profiles compared to a lower accumulation of android fat in young overweight males?
Preferential fat accumulation in the android compartment in overweight young males is associated with increased cardiovascular and metabolic risk markers, including impaired endothelial function and dyslipidemia.
Absolute Event Rate: 1.64% vs 2.26%
p-value: p=0.003
Objective: Excess adiposity increases the risk of type-2 diabetes and cardiovascular disease development. Beyond the simple level of adiposity, the pattern of fat distribution may influence these risks. We sought to examine if higher android fat distribution was associated with different hemodynamic, metabolic or vascular profile compared to a lower accumulation of android fat deposits in young overweight males. Methods: Forty-six participants underwent dual-energy X-ray absorptiometry and were stratified into 2 groups. Group 1: low level of android fat (9.5%). Assessments comprised measures of plasma lipid and glucose profile, blood pressure, endothelial function reactive hyperemia index (RHI) and muscle sympathetic nerve activity (MSNA). Results: There were no differences in weight, BMI, total body fat and lean mass between the 2 groups. Glucose tolerance and insulin resistance (fasting plasma insulin) were impaired in group 2 (p<0.05). Levels of plasma triglycerides and 5 lipid species were higher in group 2 (p<0.05). Endothelial function was less in group 2 (RHI: 1.64 vs 2.26, p=0.003) and heart rate was higher (76 vs 67 bpm, p=0.004). No difference occurred in MSNA nor blood pressure between the 2 groups. Conclusion: Preferential fat accumulation in the android compartment is associated with increased cardiovascular and metabolic risk via alteration of endothelial function.
Sari et al. (Wed,) conducted a cross-sectional in Overweight (n=46). Higher android fat content (>9.5% of total fat) vs. Lower android fat content (<9.5% of total fat) was evaluated on Endothelial function (Reactive Hyperemia Index) (p=0.003). Higher android fat deposition in overweight young males was associated with significantly reduced endothelial function (RHI 1.64 vs 2.26) and impaired metabolic profile compared to lower android fat.