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Treatment effects calculated from pilot or feasibility studies should not be the basis of a sample size calculation for a main trial, as the MID to be detected should be based primarily on clinical judgement rather than statistics. Deciding on progression to a main trial based on these treatment effects is also misguided, as they will normally be imprecise, and may be biased if the pilot or feasibility study is unrepresentative of the main trial.
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Julius Sim
Pilot and Feasibility Studies
SHILAP Revista de lepidopterología
Keele University
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Julius Sim (Wed,) studied this question.
www.synapsesocial.com/papers/69dd5d6d0644c7b49d40d367 — DOI: https://doi.org/10.1186/s40814-019-0493-7