KCa3.1 inhibition with TRAM34 significantly decreased the incidence of premature ventricular contractions and shortened QTc durations in mice 3 days post-myocardial infarction.
Absolute Event Rate: 0.67% vs 12.33%
p-value: p=0.030
: Macrophage polarization leads to APD heterogeneity and post-MI arrhythmias via gap junction and KCa3.1 activation. The results provide evidences of a novel mechanism of post-MI heterogeneous repolarization and arrhythmias, rendering macrophages and KCa3.1 to be potential therapeutic targets.
Fei et al. (Tue,) conducted a other in Myocardial infarction and post-MI arrhythmias. KCa3.1 inhibition (TRAM34) vs. Vehicle (corn oil) was evaluated on Incidence of premature ventricular contractions (PVCs) in 60 minutes (p=0.030). KCa3.1 inhibition with TRAM34 significantly decreased the incidence of premature ventricular contractions and shortened QTc durations in mice 3 days post-myocardial infarction.