Plasma creatine kinase levels were significantly elevated in women with two or more features of metabolic syndrome or waist circumference >80 cm, but did not differ between those with and without polycystic ovary syndrome.
Cross-Sectional (n=660)
Creatine kinase levels are associated with markers of obesity and metabolic syndrome, such as increased waist circumference, but are not independently elevated by the presence of polycystic ovary syndrome.
Absolute Event Rate: 70% vs 59%
p-value: p=<0.01
Objective: To correlate features of metabolic syndrome with creatine kinase (CK) in women with and without polycystic ovary syndrome (PCOS) Design: Comparative cross-sectional analysis Methods. Demographic and metabolic data from Qatari women aged 18-40 years from the Qatar Biobank (97 diagnosed with PCOS, 563 controls). The primary outcome was the association between plasma CK and features of metabolic syndrome. Results: CK increased when the waist circumference was greater than 80 cm (p0.05). Conclusion: CK was associated with an increase in BMI, waist circumference greater than 80cm and 2 or more features of the metabolic syndrome, in accord with the central role of type II skeletal muscle fibers in energy metabolism and obesity. CK was, however, independent of the PCOS phenotype.
Al-Hail et al. (Wed,) conducted a cross-sectional in Polycystic Ovary Syndrome and Metabolic Syndrome (n=660). Metabolic syndrome features (≥2 parameters) vs. 0-1 metabolic syndrome parameters was evaluated on Plasma creatine kinase (CK) levels (p=<0.01). Plasma creatine kinase levels were significantly elevated in women with two or more features of metabolic syndrome or waist circumference >80 cm, but did not differ between those with and without polycystic ovary syndrome.