Cronos titin is a novel isoform necessary for proper sarcomere function in human cardiomyocytes, representing a potential new molecular mechanism in human cardiac disease.
We demonstrate that Cronos titin is expressed in developing human CMs and is able to support partial sarcomere formation in the absence of full-length titin. Furthermore, Cronos titin is necessary for proper sarcomere function in human induced pluripotent stem cell derived CMs. Additional investigation is necessary to understand the molecular mechanisms of this novel isoform and how it contributes to human cardiac disease.
Zaunbrecher et al. (Mon,) studied this question.