P4611Colchicine before percutaneous coronary intervention in acute myocardial infarction

Abstract Aims Myocardial perfusion could determine the outcome of patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). The aim of this study was to evaluate the impact of colchicine on myocardial perfusion in this population. Methods In a double-blind, randomized trial, we assigned 196 patients with STEMI undergoing PCI to two groups: the colchicine group (N=95) and the control group (N=101). The primary endpoints were the thrombolysis in myocardial infarction (TIMI) score; TIMI myocardial perfusion grade (TMPG), and TIMI frame count (TFC). The major adverse cardiovascular events (MACEs) were recorded after one month of PPCI. Results The Final TIMI flow grade, TMPG and TFC were not significantly different between the 2 groups (p=0.75, p=0.533, p=0.161; respectively). MACE include Mortality, Non-fatal myocardial infarction, target lesion/vessel revascularization were similar between the 2 groups (p=0.058). Study outcomes Characteristics Colchicine Group (n=95) Control Group (n=101) P value Discharge status Deceased 2 (2.1%) 2 (2%) 1 Alive 93 (97.9%) 99 (98%) TIMI flow grade after PCI 0 2 (2.1%) 1 (1%) 0.747 1 2 (2.1%) 4 (4%) 2 17 (17.9%) 21 (20.8%) 3 74 (77.9%) 75 (74.3%) TIMI myocardial perfusion grade 2.39±0.89 2.31±0.95 0.533 ST segment resolution Below 50 Percentage 23 (27.1%) 27 (32.1%) 0.71 Between 50 to 70 Percentage 8 (9.4%) 6 (7.1%) Above 70 Percentage 54 (63.5%) 51 (60.7%) MACE.1.Month 10 (9.9%) 3 (3.2%) 0.058 MACE.1.Month(Mortality) 4 (4.0%) 2 (2.1%) 0.451 MACE.1.Month(Non.Fatal.MI) 2 (2.0%) 0 (0%) 0.168 MACE.1.Month(TLR) 2 (2.0%) 1 (1.1%) 0.597 MACE.1.Month(TVR) 5 (5.0%) 1 (1.1%) 0.113 Conclusion In STEMI patients treated by PPCI, the effect of colchicine before PPCI was not revealed on myocardial perfusion markers.