Elevated plasma high-sensitivity C-reactive protein concentrations (highest vs lowest quartile) were associated with a significantly increased risk of all-cause mortality (HR 1.50) in middle-aged and older adults.
Cohort (n=14,220)
Yes
Does elevated hsCRP concentration increase the risk of all-cause and cause-specific mortality in middle-aged and elderly individuals?
Elevated hsCRP concentrations are significantly associated with increased risks of all-cause, cardiovascular, and cancer mortality in middle-aged and older adults.
Hazard Ratio: 1.5 (95% CI 1.31–1.72)
p-value: p=<0.001
Abstract Background The association of high-sensitivity C-reactive protein (hsCRP) with mortality is controversial. We aimed to investigate the associations of hsCRP concentrations with the risks of all-cause and cause-specific mortality and identify potential modifying factors affecting these associations among middle-aged and elderly individuals. Methods This community-based prospective cohort study included 14,220 participants aged 50+ years (mean age: 64.9 years) from the Health and Retirement Study. Cox proportional hazard models were employed to estimate the associations between the hsCRP concentrations and the risk of all-cause and cause-specific mortality with adjustment for sociodemographic and lifestyle factors, self-reported medical history, and other potential confounders. Results In total, 1730 all-cause deaths were recorded, including 725 cardiovascular- and 417 cancer-related deaths, after an 80,572 person-year follow-up (median: 6.4 years; range: 3.6–8.1 years). The comparisons of the groups with the highest (quartile 4) and lowest (quartile 1) hsCRP concentrations revealed that the adjusted hazard ratios and 95% confidence intervals were 1.50 (1.31–1.72) for all-cause mortality, 1.44 (1.13–1.82) for cardiovascular mortality, and 1.67 (1.23–2.26) for cancer mortality. The associations between high hsCRP concentrations and the risks of all-cause, cardiovascular, and cancer mortality were similar in the men and women ( P for interaction > 0.05). Conclusions Among middle-aged and older individuals, elevated hsCRP concentration could increase the risk of all-cause, cardiovascular, and cancer mortality in men and women.
Li et al. (Tue,) conducted a cohort in All-cause and cause-specific mortality (n=14,220). Elevated high-sensitivity C-reactive protein (hsCRP) concentrations vs. Lowest quartile of hsCRP (< 0.86 mg/L) was evaluated on All-cause mortality (HR 1.50, 95% CI 1.31-1.72, p=<0.001). Elevated plasma high-sensitivity C-reactive protein concentrations (highest vs lowest quartile) were associated with a significantly increased risk of all-cause mortality (HR 1.50) in middle-aged and older adults.