Implementation of a critical care pathway for acute coronary syndrome significantly improved survival from all-cause mortality compared with standard care (HR 0.75; 95% CI 0.62-0.92; P<0.01).
Cohort (n=1,687)
No
Does the implementation of a critical care pathway improve long-term survival in patients with acute coronary syndrome?
Implementation of a critical care pathway for acute coronary syndrome significantly improved long-term survival, driven by increased rates of revascularization and statin compliance.
Effect estimate: HR 0.75 (95% CI 0.62-0.92)
Absolute Event Rate: 22.2% vs 46.7%
p-value: p=< 0.01
Implementation of a critical care pathway (CCP) for acute coronary syndrome (ACS) has been shown to improve early compliance to guideline-directed therapies and reduce early mortality. Nevertheless its long-term impact on the compliance with medications or clinical outcomes remains unknown. Between 2004 and 2015, 2023 consecutive patients were admitted to our coronary care unit with ACS. We retrospectively compared the outcomes of 628 versus 1059 patients (mean age 66.1 ± 13.3 years, 74% male) managed before and after full implementation of a CCP. Compared with standard care, implementation of the CCP significantly increased coronary revascularization and long-term compliance with guideline-directed medical therapy (both P < 0.01). After a mean follow-up of 66.5 ± 44.0 months, 46.7% and 22.2% patients admitted before and after implementation of the CCP, respectively, died. Kaplan-Meier analyses showed that patients managed by CCP had better overall survival (P = 0.03) than those managed with standard care. After adjustment for clinical covariates and coronary anatomy, CCP remained independently predictive of better survival from all-cause mortality hazard ratio (HR): 0.75, 95%confidence intervals (CI): 0.62-0.92, P < 0.01. Stepwise multivariate cox regression model showed that both revascularization (HR: 0.55, 95%CI: 0.45-0.68, P < 0.01) and compliance to statin (HR: 0.70, 95%CI: 0.58-0.85, P < 0.01) were accountable for the improved outcome.
Hai et al. (Thu,) conducted a cohort in Acute coronary syndrome (ACS) (n=1,687). Critical care pathway (CCP) vs. Standard care was evaluated on All-cause mortality (HR 0.75, 95% CI 0.62-0.92, p=< 0.01). Implementation of a critical care pathway for acute coronary syndrome significantly improved survival from all-cause mortality compared with standard care (HR 0.75; 95% CI 0.62-0.92; P<0.01).