The provided text contains only the editorial board and masthead information for the journal Thrombosis and Haemostasis, with no clinical study data available for extraction.
Does increased fibrin clot AUC predict the composite of nonfatal MI, ischemic stroke, and CV death in patients with stable CAD on aspirin monotherapy?
In patients with stable CAD on aspirin monotherapy, an increased fibrin clot area under the curve (AUC) independently predicts future cardiovascular events, highlighting the role of altered fibrin clot dynamics in residual cardiovascular risk.
Abstract Background Despite long-term antiplatelet therapy with aspirin, recurrent cardiovascular events remain common in patients with coronary artery disease (CAD). Objective We aimed to determine whether fibrin network characteristics are predictive of vascular events in patients with stable CAD treated with aspirin monotherapy. Methods We included 786 patients with angiographically documented CAD and either prior myocardial infarction, type 2 diabetes mellitus, or both. Median follow-up time was 3 years. At inclusion, fibrin clot properties were evaluated using a turbidimetric assay and the following clot parameters were studied: (1) maximum absorbance, a measure of clot density and fiber thickness; (2) lysis time, assessing fibrinolysis potential; and (3) area under the curve (AUC), a measure of clot formation and lysis. The primary endpoint was the composite of nonfatal myocardial infarction, ischemic stroke, and cardiovascular death. Hazard ratios (HRs) were estimated using multivariable Cox proportional hazards regression. Results A total of 70 primary endpoints occurred. The primary endpoint occurred more frequently in CAD patients with increased clot AUC (crude HR for first vs. fourth quartile: 2.4 95% confidence interval 1.2–4.6, p = 0.01). This finding remained significant after adjusting for potential confounders (adjusted HR: 2.4 1.2–4.8, p = 0.01). Neither clot maximum absorbance nor lysis time showed significant association with future vascular events (adjusted HR for maximum absorbance 1.8 0.9–3.7; p = 0.09) and lysis time (1.6 0.8–3.0; p = 0.18). Conclusion We demonstrate that increased clot AUC predicts future cardiovascular events in stable CAD patients receiving aspirin monotherapy.
Neergaard‐Petersen et al. (2019) studied Stable Coronary Artery Disease. The provided text contains only the editorial board and masthead information for the journal Thrombosis and Haemostasis, with no clinical study data available for extraction.