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Our results suggest that IL-8 promotes integrin β3 upregulation and the invasion of HCC cells through activation of the PI3K/Akt pathway. The IL-8/CXCR1/CXCR2/PI3K/Akt/integrin β3 axis may serve as a potential treatment target for patients with HCC.
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Fengkai Sun
Shandong Jianzhu University
Jianping Wang
Yunnan University
Qi Sun
Hebei Medical University
SHILAP Revista de lepidopterología
Journal of Experimental & Clinical Cancer Research
Shandong University
First Affiliated Hospital of Xi'an Jiaotong University
Shandong Provincial Hospital
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Sun et al. (Mon,) studied this question.
synapsesocial.com/papers/69df6e991113c054a47a150b — DOI: https://doi.org/10.1186/s13046-019-1455-x