Does higher cumulative blood pressure exposure from young adulthood to midlife worsen gait and cognitive performance in midlife?
Cumulative exposure to higher blood pressure starting in young adulthood negatively impacts midlife mobility and cognitive function.
Exposure to higher BP levels from young to midlife is associated with worse gait and cognitive performance in midlife. Furthermore, WMH moderates the association of cumulative BP exposure with gait, but not with cognitive function in midlife. The mechanisms underpinning the impact of BP exposure on brain structure and function must be investigated in longitudinal studies using a life course approach.
Mahinrad et al. (Thu,) studied this question.