December 10, 2019Open Access

Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively

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Abstract

We showed that serotonin, through 5-HTR2A/C, interferes with breast cancer cells proliferation and metabolism by triggering two distinct signalling pathways: Jak1/STAT3 that boosts glycolysis through upregulation of PKM2, and adenylyl cyclase/PKA that enhances mitochondrial biogenesis.

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Sola‐Penna et al. (Tue,) studied this question.

synapsesocial.com/papers/69d972131ad561c673684429 https://doi.org/https://doi.org/10.1038/s41416-019-0640-1

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