Longitudinal aging from 85 to 94 years demonstrated preserved ejection fraction with decreased longitudinal systolic and diastolic function without significant change in LV mass (P<0.0001).
Cohort (n=63)
No
What are the longitudinal changes in cardiac structure and function in the very elderly from age 85 to 94?
In the very elderly, aging from 85 to 94 years is associated with preserved ejection fraction but decreased longitudinal systolic and diastolic function without significant changes in LV mass.
p-value: p=< 0.0001
BACKGROUND: People over the age of 85 are a rapidly growing age group with a high incidence of congestive heart failure (CHF), in particular heart failure with preserved ejection fraction (HFpEF). The diagnosis of CHF is challenging and longitudinal data assessing cardiac structure and function are necessary to distinguish physiologic from pathologic cardiac aging. The objective of the study was to determine longitudinal changes in cardiac struture and function from ages 85 to 94 years using home echocardiography. METHODS: Subjects were recruited from the Jerusalem Longitudinal Cohort Study. Sixty three members of the initial cohort (32F, 31M) who underwent home echocardiography at age 85 were the subjects of the current study and underwent repeat home 2-D and Doppler echocardiographic assessment at age 94. RESULTS: < 0.0001) was reduced with aging. CONCLUSIONS: This study demonstrated preserved EF with decreased longitudinal systolic function and diastolic function without significant change in LV mass. Changes in LV function in the very elderly may be independent of changes in LV geometry.
Leibowitz et al. (Fri,) conducted a cohort in Very elderly (n=63). Longitudinal aging vs. Baseline at age 85 was evaluated on Longitudinal changes in cardiac structure and function (p=< 0.0001). Longitudinal aging from 85 to 94 years demonstrated preserved ejection fraction with decreased longitudinal systolic and diastolic function without significant change in LV mass (P<0.0001).