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Collectively, these data demonstrate the feasibility of using the CRISPR-Cas9 system to model loss of candidate tumor suppressor genes in SCLC, and we anticipate that this approach will facilitate efforts to investigate mechanisms driving tumor progression in this deadly disease.
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Sheng Rong Ng
Agency for Science, Technology and Research
William M. Rideout
Massachusetts Institute of Technology
Elliot H. Akama‐Garren
Harvard University
Proceedings of the National Academy of Sciences
Massachusetts Institute of Technology
Howard Hughes Medical Institute
Brigham and Women's Hospital
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Ng et al. (Mon,) studied this question.
synapsesocial.com/papers/6a01dbc71487eb4b96caf50a — DOI: https://doi.org/10.1073/pnas.1821893117