Astragalus Polysaccharide Attenuates Cisplatin‐Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction

leakage. Subsequently, APS reduced the cisplatin-induced apoptosis in mice renal and HK-2 cells. In conclusion, our data suggested that APS pretreatment might prevent cisplatin-induced kidney injury through attenuating oxidative damage, protecting mitochondria, and ameliorating mitochondrial-mediated apoptosis.