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The rhBMP-2 implant was safe and, when 1.50 mg/mL was used, significantly superior to the standard of care in reducing the frequency of secondary interventions and the overall invasiveness of the procedures, accelerating fracture and wound-healing, and reducing the infection rate in patients with an open fracture of the tibia.
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Journal of Bone and Joint Surgery
University of KwaZulu-Natal
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Govender et al. (Sun,) studied this question.