Symptomatic subjects in northern China had significantly greater carotid lumen area (57.7 vs 50.4 mm2, p=0.009) and total vessel area than those in southern China.
Cross-Sectional (n=119)
Yes
Are there regional differences in carotid atherosclerotic plaque characteristics between symptomatic subjects in northern and southern China?
Symptomatic subjects in northern China have significantly larger carotid vessel size and wall thickness compared to those in southern China, suggesting regional differences in cerebrovascular disease risk.
Absolute Event Rate: 57.7% vs 50.4%
p-value: p=0.009
Background and purpose To investigate differences in the characteristics of carotid atherosclerotic plaques of symptomatic subjects in northern and southern China using MRI. Methods Sixty-three subjects in northern China (mean age: 59.1±8.6 years, 45 men) and 56 subjects in southern China (mean age: 60.4±8.6 years, 38 men) were included. All subjects underwent carotid artery multicontrast vessel wall MRI. Plaque morphology, calcification, lipid-rich necrotic core, intraplaque haemorrhage, luminal surface disruption and high-risk plaque were measured and identified. All plaque characteristics were compared between subjects in northern and southern China using Mann-Whitney U test or χ 2 test. Results Compared with subjects in southern China, those in northern China had significantly greater areas for lumen (57.7±14.9 mm 2 vs 50.4±18.3 mm 2 , p=0.009), wall (38.4±13.1 mm 2 vs 31.9±11.7 mm 2 , p0.05). Conclusion Subjects in northern China have significantly larger vessel size and may have a higher prevalence of vulnerable plaques than those in southern China. Our findings provide additional perspective to optimise the management of cerebrovascular disease in individuals in different regions in China. Trial registration number NCT02017756
Yang et al. (Wed,) conducted a cross-sectional in Carotid atherosclerotic plaques (n=119). Northern China residence vs. Southern China residence was evaluated on Lumen area (mm2) (p=0.009). Symptomatic subjects in northern China had significantly greater carotid lumen area (57.7 vs 50.4 mm2, p=0.009) and total vessel area than those in southern China.
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