Are systemic ventricular strain and torsion measured by magnetic resonance predictive of elevated serum NT-proBNP in Fontan patients?
In Fontan patients, systemic ventricular strain and peak systolic torsion measured by MRI are better indicators of subclinical dysfunction and elevated NT-proBNP than traditional measures like ejection fraction.
GLS is an earlier marker of contractile dysfunction in repair Fontan patients. Peak systolic torsion may be a biomarker for determining subclinical dysfunction, as it is more strongly correlated with serum biomarkers of ventricular function than ventricular size or ejection fraction.
Hu et al. (2020) studied this question.