Higher baseline high-sensitivity C reactive protein (quartile 4 vs 1) was associated with an increased risk of all-cause mortality (HR 1.95; 95% CI 1.42-2.69) in a Brazilian adult cohort.
Cohort (n=14,238)
Does higher hsCRP level increase the risk of all-cause mortality in a multiethnic Brazilian population?
Higher hsCRP levels are independently associated with an increased risk of all-cause mortality in a highly admixed Brazilian population.
Effect estimate: HR 1.95 (95% CI 1.42-2.69)
BACKGROUND: High-sensitivity C reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of hsCRP with the risk of all-cause mortality in a multiethnic Brazilian population. METHODS: Baseline data (2008-2010) of a cohort of 14 238 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. hsCRP was assayed with immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after a mean follow-up of 8.0±1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease. RESULTS: The risk of death increased steadily by quartiles of hsCRP, from 1.45 (95% CI 1.05 to 2.01) in quartile 2 to 1.95 (95% CI 1.42 to 2.69) in quartile 4, compared with quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the HR was unaffected by the exclusion of participants who had self-reported medical history of diabetes, cancer and chronic obstructive pulmonary disease. CONCLUSIONS: Our study shows that hsCRP level is associated with mortality in a highly admixed population, independent of a large set of lifestyle and clinical variables.
Maluf et al. (Wed,) conducted a cohort in General adult population (n=14,238). High-sensitivity C reactive protein (hsCRP) quartile 4 vs. hsCRP quartile 1 was evaluated on All-cause mortality (HR 1.95, 95% CI 1.42-2.69). Higher baseline high-sensitivity C reactive protein (quartile 4 vs 1) was associated with an increased risk of all-cause mortality (HR 1.95; 95% CI 1.42-2.69) in a Brazilian adult cohort.