Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

Key Points

Key points are not available for this paper at this time.

Abstract

This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53- Mouse double minute 2 homolog (MDM2) protein-protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Anastasia A. Beloglazkina

University of Denver

N. V. Zyk

Lomonosov Moscow State University

Alexander G. Majouga

D. Mendeleyev University of Chemical Technology of Russia

Journals

Molecules

Actions

Institutions

Lomonosov Moscow State University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Beloglazkina et al. (Sat,) studied this question.

synapsesocial.com/papers/6a1ff5a575fc4a116b2e5a7d — DOI: https://doi.org/10.3390/molecules25051211

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Binding of an inhibitor of the p53/MDM2 Interaction to MDM2· 2003 · 56 citations
Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells· 2002 · 166 citations
p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents· 2017 · 38 citations
Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome· 2007 · 264 citations
Mdm2 in Evolution· 2012 · 44 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Binding of an inhibitor of the p53/MDM2 Interaction to MDM2· 2003 · 56 citations
Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells· 2002 · 166 citations
p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents· 2017 · 38 citations
Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome· 2007 · 264 citations
Mdm2 in Evolution· 2012 · 44 citations

Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider