Monocyte/HDL ratio was significantly higher in patients with non-dipper hypertension compared to dipper hypertension (0.029 vs 0.013, p<0.001) and was associated with end-organ damage.
Cross-Sectional (n=143)
No
Does the monocyte/HDL ratio predict end-organ damage in patients with dipper and non-dipper hypertension?
The monocyte/HDL ratio is a simple, non-invasive marker that correlates with non-dipper hypertension status and the presence of hypertensive end-organ damage such as left ventricular hypertrophy and retinopathy.
Absolute Event Rate: 0.029% vs 0.013%
p-value: p=<0.001
OBJECTIVE: We aimed to investigate whether a simple and easily calculated parameter such as monocyte/ HDL ratio (MHR) may be used in predicting non-dipper (NDHT)-dipper HT (DHT) end organ damage. METHODS: 70 NDHT and 73 DHT patient groups were included in the study according to ambulatory blood pressure screening results. Basic laboratory parameters and spot urine samples were evaluated. Transthoracic echocardiography and ophthalmological examination were performed for end-organ damages. RESULTS: The MHR among the groups was higher in the NDHT group; which was statistically significant (p≤0.001). In the NDHT group, albumin, creatinine, protein values, protein/creatinine ratio in the spot urine were significantly higher than in the DHT group (p≤0.05). Left ventricular hypertrophy (LVH) and retinopathy were also more frequently observed in the NDHT group (p≤0.001 and p=0.001, respectively). MHR in patients with LVH and retinopathy was significantly higher than in those without these complications (p=0.001). CONCLUSION: Easy to use, non-invasive and simple calculation, MHR can be used to predict end organ damage in hypertensive cases, and can be also used to distinguish between DHT/NDHT groups. This data supports the role of inflammation (Tab. 7, Ref. 14).
Kaplan et al. (Mon,) conducted a cross-sectional in Hypertension (n=143). Non-dipper hypertension vs. Dipper hypertension was evaluated on Monocyte/HDL ratio (p=<0.001). Monocyte/HDL ratio was significantly higher in patients with non-dipper hypertension compared to dipper hypertension (0.029 vs 0.013, p<0.001) and was associated with end-organ damage.