Increasing age (slope -0.014) and female gender (slope -0.212) were independently associated with lower coronary flow reserve in angiographically non-obstructed coronary arteries.
Observational (n=390)
Yes
Do clinical and haemodynamic factors influence coronary flow reserve and coronary flow capacity in patients with non-obstructed coronary arteries?
Age and female gender are associated with lower coronary flow reserve, whereas only age is associated with worse coronary flow capacity, suggesting CFC is less sensitive to clinical and haemodynamic variations than CFR.
Effect estimate: slope -0.014 (95% CI -0.021 to -0.007)
p-value: p=<0.001
AIMS: Coronary flow reserve (CFR) is a physiological index for the assessment of myocardial flow impairment due to focal or microcirculatory coronary artery disease (CAD). Coronary flow capacity (CFC) is another flow-based concept in diagnosing ischaemic heart disease, based on hyperaemic average peak velocity (hAPV) and CFR. We evaluated clinical and haemodynamic factors which potentially influence CFR and CFC in non-obstructed coronary arteries. METHODS AND RESULTS: Intracoronary Doppler flow velocity measurements to obtain CFR and CFC were performed after inducing hyperaemia in 390 non-obstructed vessels of patients who were scheduled for elective percutaneous coronary intervention (PCI) of another vessel. Akaike's information criterion (AIC) revealed age, female gender, history of myocardial infarction, hypercholesterolaemia, diastolic blood pressure, oral nitrates and rate pressure product as independent predictors of CFR and CFC. After regression analysis, age and female gender were associated with lower CFR and age was associated with worse CFC in angiographically non-obstructed vessels. CONCLUSIONS: Age and female gender are associated with lower CFR, and age with worse CFC in an angiographically non-obstructed coronary artery. CFC seems to be less sensitive to variations in clinical and haemodynamic parameters than CFR and is therefore a promising tool in contemporary clinical decision making in the cardiac catheterisation laboratory.
Stegehuis et al. (Thu,) conducted a observational in Stable or unstable angina pectoris (n=390). Age, female gender, and clinical factors was evaluated on Coronary flow reserve (CFR) (slope -0.014, 95% CI -0.021 to -0.007, p=<0.001). Increasing age (slope -0.014) and female gender (slope -0.212) were independently associated with lower coronary flow reserve in angiographically non-obstructed coronary arteries.