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Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotizing lymphadenitis that was first described in Japan in 1972. It is most commonly seen in women younger than the age of 30 years. The typical presentation includes cervical lymphadenopathy, fever, and cutaneous rash. Less often, KFD can present with axillary and mesenteric lymphadenopathy, splenomegaly, parotid gland enlargement, arthralgia, myalgia, and interstitial lung disease. Diagnosis of KFD is made when a lymph node biopsy shows necrotizing lymphadenitis with karyorrhexis and absence of granulocytes. The etiology of the disease is unknown, but an autoimmune or a postinfectious process has been proposed. Parvovirus 19, hepatitis B, HTLV-1, and toxoplasma are believed to be associated with KFD.
Shabana et al. (Tue,) studied this question.
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