The platelet phenotype may change in disease. We previously demonstrated in patients with myocardial infarction (MI) and in a murine model of MI that platelets synthesize and secrete activated matrix metalloproteinase 9. This was not observed in healthy individuals (11,22). Enhanced platelet
“Our investigation suggests that drugs that suppress platelet activity protect against the development and progression of abdominal aortic aneurysms. The findings have important implications for a potential role of antiplatelet therapy in the condition.”
Elbadawi et al. (Mon,) studied this question.