Carvedilol prevents spontaneous arrhythmogenic Ca2+ waves and inhibits sodium and calcium currents by acting directly on the SR ryanodine receptor Ca2+ release channel in adult atrial myocytes.
Does carvedilol prevent arrhythmogenic Ca2+ waves in adult atrial myocytes?
Carvedilol exerts direct antiarrhythmic effects in adult atrial myocytes by acting on the SR ryanodine receptor Ca2+ release channel to prevent arrhythmogenic Ca2+ waves, though it also inhibits sodium and calcium currents leading to ECC failure.
Here we show that the clinically widely used β-blocker carvedilol has profound effects on Ca 2+ signaling and ion currents, but also antiarrhythmic effects in adult atrial myocytes. Carvedilol inhibits sodium and calcium currents and leads to failure of ECC but also prevents spontaneous Ca 2+ release from cellular sarcoplasmic reticulum (SR) Ca 2+ stores in form of arrhythmogenic Ca 2+ waves. The antiarrhythmic effect occurs by carvedilol acting directly on the SR ryanodine receptor Ca 2+ release channel.
Martínez‐Hernández et al. (Fri,) conducted a other in Arrhythmogenicity in adult atrial myocytes. Carvedilol was evaluated on Ca2+ signaling, ion currents, and arrhythmogenic Ca2+ waves. Carvedilol prevents spontaneous arrhythmogenic Ca2+ waves and inhibits sodium and calcium currents by acting directly on the SR ryanodine receptor Ca2+ release channel in adult atrial myocytes.