Individuals with higher common carotid artery diameters and monocyte counts had a higher risk of incident heart failure or all-cause death (adjusted HR 2.81; 95% CI 1.57-5.03; P<0.001).
Cohort (n=2,085)
Does a higher circulating monocyte count predict ventricular-arterial remodeling and incident heart failure in asymptomatic subjects?
Elevated circulating monocyte counts and larger common carotid artery diameters are independently associated with cardiac remodeling and a significantly higher risk of incident heart failure or death in asymptomatic individuals.
Hazard Ratio: 2.81 (95% CI 1.57–5.03)
p-value: p=<0.001
Among 2085 asymptomatic subjects (age: 51.0 ± 10.7 years, 41.3% female) with data available on common carotid artery diameter (CCAD) and circulating total white blood cell (WBC) counts, higher circulating leukocytes positively correlated with higher high sensitivity C-reactive protein (hs-CRP). Higher WBC/segmented cells and monocyte counts were independently associated with greater relative wall thicknesses and larger CCADs, which in general were more pronounced in men and obese subjects (body mass index ≥ 25 kg/m2) (all P interaction: < 0.05). Using multivariate adjusting models, only the monocyte count independently predicted the left ventricular mass index (LVMi) (ß-Coef: 0.06, p = 0.01). Higher circulating WBC, segmented, and monocyte counts and a greater CCAD were all independently associated with a higher risk of heart failure (HF)/all-cause death during a median of 12.1 years of follow-up in fully adjusted models, with individuals manifesting both higher CCADs and monocyte counts incurring the highest risk of HF/death (adjusted hazard ratio: 2.81, 95% CI: 1.57. −5.03, p < 0.001; P interaction, 0.035; lower CCAD/lower monocyte as reference). We conclude that a higher monocyte count is associated with cardiac remodeling and carotid artery dilation. Both an elevated monocyte count and a larger CCAD may indicate a specific phenotype that confers the highest risk of HF, which likely signifies the role of circulating monocytes in the pathophysiology of heart failure with preserved ejection fraction (HFpEF).
Wang et al. (Fri,) conducted a cohort in Incident heart failure (n=2,085). Higher monocyte count and larger common carotid artery diameter vs. Lower CCAD and lower monocyte count was evaluated on Heart failure or all-cause death (HR 2.81, 95% CI 1.57-5.03, p=<0.001). Individuals with higher common carotid artery diameters and monocyte counts had a higher risk of incident heart failure or all-cause death (adjusted HR 2.81; 95% CI 1.57-5.03; P<0.001).