Plasma metabolomic profiling demonstrated significant sexual dimorphism in arterial hypertension, identifying 75 discriminant metabolites in women and 65 in men with good predictive performance.
Case-Control (n=64)
No
Does the plasma metabolomic profile differ between men and women with essential arterial hypertension compared to healthy controls?
This study identifies a sexually dimorphic metabolomic signature in essential arterial hypertension, highlighting the importance of sex-specific metabolic pathways in the disease.
Effect estimate: Q2cum = 0.59 in women and 0.60 in men
p-value: p=0.004
Abstract Metabolomic studies have demonstrated the existence of biological signatures in blood of patients with arterial hypertension, but no study has hitherto reported the sexual dimorphism of these signatures. We compared the plasma metabolomic profiles of 28 individuals (13 women and 15 men) with essential arterial hypertension with those of a healthy control group (18 women and 18 men), using targeted metabolomics. Among the 188 metabolites explored, 152 were accurately measured. Supervised OPLS-DA (orthogonal partial least squares-discriminant analysis) showed good predictive performance for hypertension in both sexes (Q 2 cum = 0.59 in women and 0.60 in men) with low risk of overfitting ( p -value-CV ANOVA = 0.004 in women and men). Seventy-five and 65 discriminant metabolites with a VIP (variable importance for the projection) greater than 1 were evidenced in women and men, respectively. Both sexes showed a considerable increase in phosphatidylcholines, a decrease in C16:0 with an increase in C28:1 lysophosphatidylcholines, an increase in sphingomyelins, as well as an increase of symmetric dimethylarginine (SDMA), acetyl-ornithine and hydroxyproline. Twenty-nine metabolites, involved in phospholipidic and cardiac remodeling, arginine/nitric oxide pathway and antihypertensive and insulin resistance mechanisms, discriminated the metabolic sexual dimorphism of hypertension. Our results highlight the importance of sexual dimorphism in arterial hypertension.
Goïta et al. (Tue,) conducted a case-control in Essential arterial hypertension (n=64). Arterial hypertension vs. Healthy controls was evaluated on Predictive performance of OPLS-DA model for hypertension (Q2cum = 0.59 in women and 0.60 in men, p=0.004). Plasma metabolomic profiling demonstrated significant sexual dimorphism in arterial hypertension, identifying 75 discriminant metabolites in women and 65 in men with good predictive performance.
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