Surfactant Self-Assembling and Critical Micelle Concentration: One Approach Fits All?

-lauroyl sarcosinate) and two nonionic, such as polyethylene glycol ester surfactants polyethylenglicol (8) monostearate and polyethylenglicol (8) monolaurate, have been determined by this approach. The "second-derivate" approach provides a reliable determination of the CMC values among all of the techniques investigated, which were comparable to those calculated by the other operator-free routinely methods employed, such as segmental linear regression or Boltzmann regression. This study also highlighted the strengths and shortcomings of each technique over the others, providing an overview of the CMC values of commonly used anionic and nonionic surfactants in the pharmaceutical field, determined by employing different experimental approaches.