Patients with structural coronary microvascular dysfunction experience diminished peak coronary blood flow augmentation during exercise compared to those with functional dysfunction.
Differentiating between functional and structural coronary microvascular dysfunction highlights distinct pathophysiological mechanisms that may warrant stratified therapeutic approaches.
Absolute Event Rate: 0% vs 0%
Functional CMD is characterized by elevated resting flow that is linked to enhanced NOS activity. Patients with structural CMD have endothelial dysfunction, which leads to diminished peak CBF augmentation and increased demand during exercise. The value of pathophysiologically stratified therapy warrants investigation.
Rahman et al. (Fri,) reported a other. Patients with structural coronary microvascular dysfunction experience diminished peak coronary blood flow augmentation during exercise compared to those with functional dysfunction.