Carotid magnetic resonance imaging is a validated tool for quantifying plaque vulnerability, with intraplaque hemorrhage serving as a strong independent risk predictor for stroke.
Does carotid MRI accurately assess plaque vulnerability and predict stroke risk in patients with carotid plaques?
Carotid MRI is a highly validated imaging modality for assessing plaque vulnerability, with intraplaque hemorrhage serving as a powerful independent predictor of future stroke risk.
Abstract: Rupture of a vulnerable carotid plaque is one of the leading causes of stroke. Carotid magnetic resonance imaging (MRI) is able to visualize all the main hallmarks of plaque vulnerability. Various MRI sequences have been developed in the last two decades to quantify carotid plaque burden and composition. Often, a combination of multiple sequences is used. These MRI techniques have been extensively validated with histological analysis of carotid endarterectomy specimens. High agreement between the MRI and histological measures of plaque burden, intraplaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), fibrous cap (FC) status, inflammation and neovascularization has been demonstrated. Novel MRI sequences allow to generate three-dimensional isotropic images with a large longitudinal coverage. Other new sequences can acquire multiple contrasts using a single sequence leading to a tremendous reduction in scan time. IPH can be easily identified as a hyperintense signal in the bulk of the plaque on strongly T1-weighted images, such as magnetization-prepared rapid acquisition gradient echo images, acquired within a few minutes with a standard neurovascular coil. Carotid MRI can also be used to evaluate treatment effects. Several meta-analyses have demonstrated a strong predictive value of IPH, LRNC, thinning or rupture of the FC for ischemic cerebrovascular events. Recently, in a large meta-analysis based on individual patient data of asymptomatic and symptomatic individuals with carotid artery stenosis, it was shown that IPH on MRI is an independent risk predictor for stroke, stronger than any known clinical risk parameter. Expert recommendations on carotid plaque MRI protocols have recently been described in a white paper. The present review provides an overview of the current status and applications of carotid plaque MR imaging and its future potential in daily clinical practice.
Kassem et al. (2020) conducted a review in Carotid plaques. Carotid magnetic resonance imaging (MRI) was evaluated. Carotid magnetic resonance imaging is a validated tool for quantifying plaque vulnerability, with intraplaque hemorrhage serving as a strong independent risk predictor for stroke.