Psoriasis is associated with a 30-50% frequency of cardio-metabolic syndrome, with proteins like PSCK9, ANGPLT8, SORT1, and CEPT serving as plausible links between the conditions.
This review highlights the potential roles of PCSK9, ANGPLT8, SORT1, and CETP in the pathophysiological link between psoriasis and cardio-metabolic syndrome.
Psoriasis is a systemic, immune-metabolic disease with strong genetic predispositions and autoimmune pathogenic traits. During psoriasis progression, a wide spectrum of comorbidities comes into play with the leading role of the cardio-metabolic syndrome (CMS) that occurs with the frequency of 30-50% amongst the psoriatic patients. Both conditions-psoriasis and CMS-have numerous common pathways, mainly related to proinflammatory pathways and cytokine profiles. Surprisingly, despite the years of research, the exact pathways linking the occurrence of CMS in the psoriasis population are still not fully understood. Recently published papers, both clinical and based on the basic science, shed new light into this relationship providing an insight into novel key-players proteins with plausible effects on above-mentioned interplay. Taking into account recent advances in this important medical matter, this review aims to discuss comprehensively the role of four proteins: proprotein convertase subtilisin/kexin type-9 (PSCK9), angiopoietin-like protein 8 (ANGPLT8), sortilin (SORT1), and cholesteryl ester transfer proteins (CEPT) as plausible links between psoriasis and CMS.
Krahel et al. (Sat,) conducted a review in Psoriasis and cardio-metabolic syndrome. PSCK9, ANGPLT8, SORT1, and CEPT was evaluated. Psoriasis is associated with a 30-50% frequency of cardio-metabolic syndrome, with proteins like PSCK9, ANGPLT8, SORT1, and CEPT serving as plausible links between the conditions.