Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β -4.39; 95% CI -7.36 to -1.43; p=0.004) and the 15-Picture Learning Test among older adults.
Observational (n=4,428)
Is higher variability in HDL-c over time associated with worse cognitive function in older adults?
Higher intraindividual variability in HDL-c over time is associated with worse cognitive function in older adults.
Effect estimate: β -4.39 (95% CI -7.36 to -1.43)
p-value: p=0.004
Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person’s repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β 95% confidence interval CI = −4.39 −7.36, −1.43, p = .004), immediate recall on the 15-Picture Learning Test (β 95% CI = −0.98 −1.86, −0.11, p = .027), and delayed recall on the 15-Picture Learning Test (β 95% CI = −1.90 −3.14, −0.67, p = .002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults.
Grasset et al. (Wed,) conducted a observational in Older adults (n=4,428). High-density lipoprotein cholesterol (HDL-c) variability was evaluated on Performance on the Letter-Digit Coding Test (β -4.39, 95% CI -7.36 to -1.43, p=0.004). Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β -4.39; 95% CI -7.36 to -1.43; p=0.004) and the 15-Picture Learning Test among older adults.