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B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling | Synapse

June 12, 2020Open Access

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling

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Resumen

Our data underline a unique role of the B55α/PP2A phosphatase complex in vessel remodeling and suggest the use of PP2A-inhibitors as potent antiangiogenic drugs targeting specifically nascent blood vessels with a mode-of-action complementary to VEGF-R (vascular endothelial growth factor receptor)-targeted therapies. Graphical Abstract: A graphical abstract is available for this article.

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Cite This Study

Ehling et al. (Fri,) studied this question.

synapsesocial.com/papers/69dbd06650e1971baba3ce58 https://doi.org/https://doi.org/10.1161/circresaha.119.316071