Late potential abolition and VT noninducibility during VT ablation in nonischemic cardiomyopathy were associated with improved free survival from VT (HR 0.45) and cardiac death (HR 0.38).
Cohort (n=403)
Does achieving the combination of late potential abolition and VT noninducibility improve free survival from VT and cardiac death in patients with nonischemic cardiomyopathy undergoing VT ablation?
Achieving both late potential abolition and VT noninducibility during VT ablation in patients with nonischemic cardiomyopathy is associated with significantly reduced risks of VT recurrence and cardiac death.
Effect estimate: HR 0.45 for VT, HR 0.38 for cardiac death (95% CI 0.29-0.69 for VT, 0.18-0.74 for cardiac death)
p-value: p=0.0002 for VT, 0.005 for cardiac death
Background: In patients with an ischemic cardiomyopathy (ICM), the combination of late potential (LP) abolition and postprocedural ventricular tachycardia (VT) noninducibility is known to be the desirable end point for a successful long-term outcome after VT ablation. We investigated whether LP abolition and VT noninducibilty have a similar impact on the outcomes of patients with non-ICMs (NICM) undergoing VT ablation. Methods: A total of 403 patients with NICM (523 procedures) who underwent a VT ablation from 2010 to 2016 were included. The procedure end points were the LP abolition (if the LPs were absent, other ablation strategies were undertaken) and the VT noninducibilty. Results: The underlying structural heart disease consisted of dilated cardiomyopathy (DCM, 49%), arrhythmogenic right ventricular dysplasia (ARVD, 17%), postmyocarditis (14%), valvular heart disease (8%), congenital heart disease (2%), hypertrophic cardiomyopathy (2%), and others (5%). The epicardial access was performed in 57% of the patients. At baseline, the LPs were present in 60% of the patients and a VT was either inducible or sustained/incessant in 85% of the cases. At the end of the procedure, the LP abolition was achieved in 79% of the cases and VT noninducibility in 80%. After a multivariable analysis, the combination of LP abolition and VT noninducibilty was independently associated with free survival from VT (hazard ratio, 0.45 95% CI, 0.29–0.69, P =0.0002) and cardiac death (hazard ratio, 0.38 95% CI, 0.18–0.74, P =0.005). The benefit of the LP abolition on preventing the VT recurrence in patients with ARVD and postmyocarditis appeared superior to that observed for those with DCM. Conclusions: In patients with NICM undergoing VT ablation, the strategy of LP abolition and VT noninducibilty were associated with better outcomes in terms of long-term VT recurrences and cardiac survival. Graphic Abstract: A graphic abstract is available for this article.
Okubo et al. (Mon,) conducted a cohort in Nonischemic Cardiomyopathy (n=403). Ventricular tachycardia ablation with late potential abolition and VT noninducibility was evaluated on Free survival from VT and cardiac death (HR 0.45 for VT, HR 0.38 for cardiac death, 95% CI 0.29-0.69 for VT, 0.18-0.74 for cardiac death, p=0.0002 for VT, 0.005 for cardiac death). Late potential abolition and VT noninducibility during VT ablation in nonischemic cardiomyopathy were associated with improved free survival from VT (HR 0.45) and cardiac death (HR 0.38).